Why Do Symptoms Happen?

Hot flashes and night sweats occur when low estrogen tricks your brain into thinking your body is too warm—even though it's not. Blood vessels near the surface of your skin increase circulation to cool your body temperature. Your face and neck feel hot and may look red and flushed.

Hot flashes can occur at any time (usually an inconvenient one) during the day, while night sweats can wake you up.

Women undergoing natural menopause have been using the CLIMARA PRO^® transdermal patch for years to relieve these moderate to severe menopausal symptoms.

Ask your healthcare provider if the CLIMARA PRO patch may be right for you.

Important Safety Information

What is CLIMARA used for?

CLIMARA is used after menopause to:

Reduce moderate to severe hot flashes
Treat moderate to severe dryness, itching, and burning in or around the vagina
Treat certain conditions in which a young woman's ovaries do not produce enough estrogen naturally
Help reduce your chances of getting osteoporosis (thin weak bones)

When prescribing solely for vaginal dryness or osteoporosis, other treatments should be considered.

What is the most important information I should know about CLIMARA (an estrogen hormone)?

Estrogens increase the chances of getting cancer of the uterus.

Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia.

Using estrogens with or without progestins may increase your chances of getting heart attack, strokes, breast cancer, and blood clots. Using estrogens with progestins may increase your risk of dementia.

You and your healthcare provider should talk regularly about whether you still need treatment with CLIMARA.

What is CLIMARA PRO used for?

CLIMARA PRO is used after menopause to:

Reduce moderate to severe hot flashes.
Help prevent osteoporosis (thin weak bones).

When prescribing solely for osteoporosis, other treatments should be considered.

What is the most important information I should know about CLIMARA PRO (combination of estrogen and progestin hormones)?

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes.

Using estrogens and progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots.

Do not use estrogens with or without progestins to prevent dementia

Using estrogens with progestins may increase your risk of dementia.

You and your healthcare provider should talk regularly about whether you still need treatment with CLIMARA PRO.

Who should not use CLIMARA and CLIMARA PRO? Do not use CLIMARA PRO if you have had your uterus removed (hysterectomy).

Do not start using CLIMARA if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, currently have or have had liver problems, are allergic to CLIMARA or CLIMARA PRO or any of its ingredients, or think you may be pregnant.

What are the warnings of less common but serious side effects of CLIMARA or CLIMARA PRO?

Warnings of less common but serious side effects of CLIMARA or CLIMARA PRO include breast lumps, unusual vaginal bleeding, dizziness and faintness, changes in speech, severe headaches, chest pain, shortness of breath, pains in your legs, changes in vision, and vomiting. Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

What are common side effects of CLIMARA or CLIMARA PRO?

Common side effects of CLIMARA include headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps, bloating, nausea and vomiting, and hair loss.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.